EL DOBLE PAPEL DE LAS ESPECIES REACTIVAS DE OXÍGENO EN EL METABOLISMO CELULAR
THE DUAL ROLE OF REACTIVE OXYGEN SPECIES IN CELLULAR METABOLISM
Autor(es): M. E. Bibián-León
Fuente: Mexican Journal of Technology and Engineering, Vol. 1, No. 1, pp. 4-8.
DOI: https://doi.org/10.61767/mjte.001.1.0408
Resumen
Las reacciones bioquímicas celulares producen moléculas altamente reactivas e inestables denominadas Especies Reactivas de Oxígeno. Estas moléculas continuamente causan daños que, de no controlarse, llevan a muerte celular. Sin embargo, cuando la concentración de las Especies Reactivas de Oxígeno se mantiene en niveles bajos o fisiológicos, fungen como moléculas señalizadoras en procesos metabólicos como lo es la producción de metabolitos secundarios. Estos metabolitos son de interés ya que muchos de ellos tienen efectos farmacológicos y toxicológicos sobre el ser humano. Por ello, dependiendo de la concentración de las Especies Reactivas de Oxígeno dentro de la célula, éstas tienen una doble función en su metabolismo.
Palabras clave: Especies reactivas de oxígeno, metabolitos secundarios, hongos filamentosos.
Abstract
The cellular biochemical reactions produce highly reactive and unstable molecules called Reactive Oxygen Species. These molecules continually cause damage that, if left unchecked, leads to cell death. However, when the low or physiological concentration of Reactive Oxygen Species is maintained, they function as signaling molecules in metabolic processes such as the production of secondary metabolites. These metabolites are of interest since some have pharmacological and toxicological effects on humans. Therefore, depending on the concentration of Reactive Oxygen Species within the cell, they have a double function in its metabolism.
Keywords: Reactive Oxygen Species, secondary metabolism, filamentous fungi.
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